ELK Biotechnology Lck (phospho Tyr505) rabbit pAb
Lck 단백질의 Tyr505 인산화 부위를 인식하는 rabbit polyclonal antibody. WB, IHC, IF, ELISA에 사용 가능. 인간, 생쥐, 랫트 시료 반응성. 세포막 및 세포질 내 비활성 형태 존재. T세포 발달 신호전달 연구에 적합.
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제품명
Lck (phospho Tyr505) rabbit pAb
제품 개요
본 항체는 인간 Lck 단백질의 Tyr505 인산화 부위를 기반으로 제작된 rabbit polyclonal antibody로, 다양한 면역학적 분석(WB, IHC, IF, ELISA)에 활용 가능합니다. T세포 발달 및 신호전달 연구에 유용합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Lck (phospho Tyr505) rabbit pAb |
| Alternative Names | LCK; Tyrosine-protein kinase Lck; Leukocyte C-terminal Src kinase; LSK; Lymphocyte cell-specific protein-tyrosine kinase; Protein YT16; Proto-oncogene Lck; T cell-specific protein-tyrosine kinase; p56-LCK |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | WB: 1/500–1/2000 IHC: 1/100–1/300 ELISA: 1/40000 (Other applications not yet tested) |
| Immunogen | Synthesized peptide derived from human Lck around the phosphorylation site of Tyr505 (AA range: 460–509) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 56 kDa |
| Gene ID (Human) | 3932 |
| Human Swiss-Prot No. | P06239 |
| Cellular Localization | Cell membrane; Lipid-anchor; Cytoplasmic side; Cytoplasm (cytosol); Present in lipid rafts in an inactive form |
| Species Reactivity | Human, Mouse, Rat |
Background
This gene encodes a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which mediate protein-protein interactions with phosphotyrosine-containing and proline-rich motifs. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors including CD4 and CD8, as well as other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described. [RefSeq, Aug 2016]
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