ELK Biotechnology Lck (phospho Tyr393) rabbit pAb
Lck 단백질의 Tyr393 인산화 부위를 인식하는 rabbit polyclonal antibody. WB, IF, ELISA에 사용 가능하며, 인간, 마우스, 랫트 시료에 반응. 세포막 및 세포질에 위치한 Src family kinase 연구에 적합.
- 판매단위
- pk
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Lck (phospho Tyr393) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Lck (phospho Tyr393) rabbit pAb |
| Alternative Names | LCK; Tyrosine-protein kinase Lck; Leukocyte C-terminal Src kinase; LSK; Lymphocyte cell-specific protein-tyrosine kinase; Protein YT16; Proto-oncogene Lck; T cell-specific protein-tyrosine kinase; p56-LCK |
| Applications | WB; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500–1/2000 Immunofluorescence: 1/200–1/1000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Lck around the phosphorylation site of Tyr393 (AA range: 361–410) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 60 kDa |
| Gene ID (Human) | 3932 |
| Human Swiss-Prot No. | P06239 |
| Cellular Localization | Cell membrane; lipid-anchor; cytoplasmic side; cytoplasm, cytosol; present in lipid rafts in an inactive form |
| Species Reactivity | Human; Mouse; Rat |
Background
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains that mediate protein–protein interactions with phosphotyrosine-containing and proline-rich motifs. The protein localizes to the plasma membrane and pericentrosomal vesicles, binding to cell surface receptors including CD4 and CD8, as well as other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described. (RefSeq, Aug 2016)
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