ELK Biotechnology Cleaved-Kininogen-1 HC (K380) rabbit pAb
Cleaved-Kininogen-1 HC (K380) rabbit polyclonal antibody로, 인간·쥐·마우스 시료에 반응합니다. WB와 ELISA에 적합하며, 혈액 응고 및 칼리크레인-키닌 시스템 연구에 유용합니다. 고순도 IgG로 -20°C에서 1년 보관 가능합니다.
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Cleaved-Kininogen-1 HC (K380) rabbit pAb
제품 개요
Cleaved-Kininogen-1 HC (K380) rabbit polyclonal antibody는 Cleaved-Kininogen-1 단백질의 특정 펩타이드 서열(AA 300-380)에 대해 생성된 항체입니다. 본 항체는 혈액 응고 및 칼리크레인-키닌 시스템 연구에 적합하며, WB 및 ELISA 분석에 사용 가능합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Cleaved-Kininogen-1 HC (K380) rabbit pAb |
| Alternative Names | KNG1; BDK; KNG; Kininogen-1; Alpha-2-thiol proteinase inhibitor; Fitzgerald factor; High molecular weight kininogen; HMWK; Williams-Fitzgerald-Flaujeac factor |
| Applications | WB; ELISA |
| Recommended Dilutions | WB: 1/500 - 1/2000 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from Cleaved-Kininogen-1 HC (K380) (AA range: 300-380) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 41 kD |
| GeneID (Human) | 3827 |
| Human Swiss-Prot No | P01042 |
| Cellular Localization | Secreted, extracellular space |
| Species Reactivity | Human; Rat; Mouse |
Background
This gene uses alternative splicing to generate two different proteins—high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Bradykinin, a peptide causing numerous physiological effects, is released from HMWK and also functions as an antimicrobial peptide with antibacterial and antifungal activity. In contrast, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.
[provided by RefSeq, Nov 2014]
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