Thermo Fisher Scientific BCOR Monoclonal Antibody (OTI4F6), TrueMAB
인간 BCOR 단백질(aa 384-668)을 인식하는 mouse IgG2b 단클론 항체로, Western blot에 최적화되어 있습니다. 동결건조 형태이며, PBS 및 trehalose 완충액에 보존됩니다. 연구용으로 사용되며, 핵심 전사 억제 단백질 분석에 적합합니다.
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4F6 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 384–668 of human BCOR produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
BCOR acts as a transcriptional corepressor that inhibits gene expression when recruited to promoter regions by DNA-binding proteins such as BCL6 and MLLT3.
This repression may involve histone deacetylase activity. BCOR is implicated in repression of TFAP2A, affecting osteo-dentiogenic capacity in adult stem cells.
It functions through inhibition of histone methylation at H3K4me3 and H3K36me2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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