Thermo Fisher Scientific PHGDH Recombinant Rabbit Monoclonal Antibody (8H10Z3)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Immunogen sequence:

EEPPRDRALV DHENVISCPH LGASTKEAQS RCGEEIAVQF VDMVKGKSLT GVVNAQALTS AFSPHTKPWI GLAEALGTLM RAWAGSPKGT IQVITQGTSL KNAGNCLSPA VIVGLLKEAS KQADVNLVNA KLLVKEAGLN VTTSHSPAAP GEQGFGECLL AVALAGAPYQ AVGLVQGTTP VLQGLNGAVF RPEVPLRRDL PLLLFRTQTS DPAMLPTMIG LLAEAGVRLL SYQTSLVSDG ETWHVMGISS LLPSLEAWKQ HVTEAFQFHF

Target Information

The PHGDH gene encodes an enzyme involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been associated with congenital microcephaly, psychomotor retardation, and other symptoms. Multiple alternatively spliced transcript variants have been identified, though the full-length nature of most remains unknown.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.