Thermo Fisher Scientific NUP98 Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:3,000
• Publications: [References not provided]

Product Specifications

Product Specific Information

• Recommended positive controls: cos7, 293T, HepG2
• Predicted reactivity: Mouse (96%), Rat (96%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins.
The 98 kDa nucleoporin is generated through a biogenesis pathway involving synthesis and proteolytic cleavage of a 186 kDa precursor protein, resulting in the 98 kDa and 96 kDa nucleoporins localized to the nucleoplasmic side of the NPC.

Rat studies show that the 98 kDa nucleoporin serves as one of several docking site nucleoporins for transport substrates.
The human NUP98 gene has been shown to fuse with several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL).

This gene is located in the imprinted gene domain of 11p15.5, an important tumor-suppressor region linked to Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and various cancers (lung, ovarian, breast).
Alternative splicing results in several transcript variants, not all of which are fully characterized.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.