Thermo Fisher Scientific VPS39 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:100-1:500

-

Immunocytochemistry (ICC/IF)

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 606-875 of human VPS39 (NP_0561042) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:VPS39,uniProtId:Q96JC1-1,ncbiNodeId:9606,antigenRange:606-875,antigenLength:886,antigenImageFileName:PA5-88969_VPS39_Q96JC1-1_Rabbit.svg,antigenImageFileNamePDP:PA5-88969_VPS39_Q96JC1-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.01 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2805263

Product Specific Information

Immunogen sequence: RFHNCLIQLY CEKVQGLMKE YLLSFPAGKT PVPAGEEEGE LGEYRQKLLM FLEISSYYDP GRLICDFPFD GLLEERALLL GRMGKHEQAL FIYVHILKDT RMAEEYCHKH YDRNKDGNKD VYLSLLRMYL SPPSIHCLGP IKLELLEPKA NLQAALQVLE LHHSKLDTTK ALNLLPANTQ INDIRIFLEK VLEENAQKKR FNQVLKNLLH AEFLRVQEER ILHQQVKCII TEEKVCMVCK KKIGNSAFAR YPNGVVVHYF CSKEVNPADT; Positive Samples: U-87MG, 293T, A-549; Cellular Location: Cytoplasm, Late endosome, Late endosome membrane, Lysosome, Lysosome membrane, Peripheral membrane protein

Target Information

VPS39 is the mammalian homolog of the yeast vacuolar protein VAM6, that in mammals, promotes lysosome clustering and fusion in vivo. VPS39 is also thought to modulate the TGF-beta response by coupling the TGF-beta receptor complex to the Smad pathway. Similar to the related protein TRAP1, the VPS39 protein is essential for early embryonic development, with mice lacking VPS39 dying at or before E6. 5.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.