Thermo Fisher Scientific CD47 Monoclonal Antibody (MEM-122), FITC

Applications

• Flow Cytometry (Flow): 20 µL/1×10⁶ cells

Product Specifications

Additional Formats

• Unconjugated (MA1-19117)
• Request custom conjugation (Form link)

Product Specific Information

This antibody reacts with an extracellular epitope of CD47 (Integrin Associated Protein), a 50–55 kDa membrane adhesion molecule (thrombospondin receptor; immunoglobulin supergene family) expressed on leukocytes, platelets, and erythrocytes. It is also expressed on epithelial cells, endothelial cells, fibroblasts, and many tumor cell lines.

Target Information

CD47 (integrin-associated protein, IAP) is a ubiquitously expressed cell surface transmembrane glycoprotein that interacts with several integrins and regulates their functions. Engagement of CD47 by soluble ligands or counter receptors modulates various signaling pathways, such as activation of heterotrimeric G proteins. Functionally, CD47 is involved in increasing intracellular calcium concentration upon cell adhesion to extracellular matrix. It also serves as a receptor for the C-terminal cell binding domain of thrombospondin, playing roles in membrane transport and signal transduction.

CD47 has broad tissue distribution and reduced expression on Rh erythrocytes. It acts as a ligand for CD172a (signal regulatory protein alpha, SIRPα), an immune inhibitory receptor on macrophages, preventing phagocytosis of CD47-positive cells. The CD47–CD172a system influences cell migration, B cell adhesion, T cell activation, and modulates chondrocyte responses to mechanical signals, promoting neuronal development, especially in synapse-rich regions of the brain and retina.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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