Thermo Fisher Scientific PIK3C2B Polyclonal Antibody

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
PHTVANGHELF EVSEERDEEV AAFCHMLDIL RSGSDIQDYF LTGYVWSAVT PSPEHLGDEV NLKVTVLCDR LQEALTFTCN CSSTVDLLIY QTLCY

Highest antigen sequence identity to the following orthologs:

• Mouse: 92%
• Rat: 90%

Target Information

The Class II PI3 kinases, including PIK3C2B, phosphorylate the 3 position of PI or PI4P. Though not as well studied as the class I PI3 kinases, the class II enzymes have been linked to diverse receptor-mediated cellular processes, including insulin signaling, neuronal survival, and growth factor signaling.

Protein kinases transfer a phosphate group from ATP onto an acceptor amino acid in substrate proteins, mediating most signal transduction in eukaryotic cells. They regulate metabolism, transcription, cell cycle progression, cytoskeletal rearrangement, apoptosis, and differentiation. With over 500 gene products, the protein kinase family is one of the largest in eukaryotes, classified into 8 major groups based on sequence comparison of tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.