Thermo Fisher Scientific Progesterone Polyclonal Antibody

Applications

• ELISA (ELISA)
  Tested Dilution: 5–10 µg/mL

Product Specifications

Product Specific Information

• Working Concentration: 0.625 µg/mL
• Sensitivity: 10 ng/mL Progesterone produces 86% inhibition in a competitive ELISA employing Progesterone polyclonal antibody.

Target Information

Progesterone is the major progestational steroid, secreted primarily by the corpus luteum and the placenta. It binds to the progesterone receptor, leading to dissociation of heat shock proteins, receptor phosphorylation, and transcription activation through direct or indirect interaction with transcription factors.
Progesterone acts on the uterus, mammary glands, and brain, and is essential for embryo implantation, pregnancy maintenance, and mammary tissue development for milk production. It is converted from pregnenolone and also serves as an intermediate in the biosynthesis of gonadal steroid hormones and adrenal corticosteroids.
Therapeutic progesterone is a synthetic form of the endogenous hormone, which inhibits estrogen activity by reducing estrogen receptor numbers and increasing metabolism to inactive metabolites.
(Source: National Center for Biotechnology Information. PubChem Compound Database; CID=5994)

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.