Thermo Fisher Scientific Tensin 3 Polyclonal Antibody
인간 Tensin 3 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, IHC(P) 및 ICC/IF 실험에 적합. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 0.3 mg/mL 농도. 세포 구조 및 신호전달 연구용에 이상적.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:200–1:500
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human Tensin 3 (Product #RP-103240) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2648382 |
Product Specific Information
Immunogen sequence:
VGSGPHPPDT QQPSPSKAFK PRFPGDQVVN GAGPELSTGP SPGSPTLDID QSIEQLNRLI LELDPTFEPI PTHMNALGSQ ANGSV
Highest antigen sequence identity to the following orthologs:
- Mouse: 69%
- Rat: 73%
Target Information
The Tensin (Tns) family of proteins is involved in maintaining cellular structure by anchoring actin filaments at the focal adhesion via F-actin binding and capping activities. These proteins also contain a Src homology 2 (SH2) domain and can be phosphorylated, indicating a role in signal transduction cascades.
Tns3 (also known as TEM6 or TENS1) localizes to focal adhesions of the plasma membrane and is predominantly expressed in thyroid and placenta, with additional expression in heart, liver, brain, prostate, pancreas, kidney, lung, skeletal muscle, and white blood cells.
Tns3 is essential for proper growth and development, as evidenced by growth retardation and death in Tns3 knockout mice.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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