Thermo Fisher Scientific ISG15 Monoclonal Antibody (OTI6C8), TrueMAB

Applications

• Western Blot (WB)
  Tested Dilution: 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).

Target Information

ISG15 is a ubiquitin-like protein involved in the innate immune response to viral infection. It acts through conjugation to target proteins (ISGylation) or as a free protein. Secreted from monocytes upon stimulation by type I interferons, ISG15 promotes NK-cell proliferation and enhances non-MHC-restricted cytotoxicity. Expression is induced by IFN-α, IFN-β, IFN-ω, and various interferon regulatory factors, as well as influenza B virus.
ISG15 functions both extracellularly and intracellularly as a ubiquitin homolog. Mutations in the ISG15 gene can lead to Immunodeficiency 38 (IMD38) with basal ganglia calcification.

For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.

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