Thermo Fisher Scientific VPS53 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human VPS53. Recombinant protein control fragment (Product #RP-93279). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:VPS53,uniProtId:Q5VIR6-4,ncbiNodeId:9606,antigenRange:238-344,antigenLength:832,antigenImageFileName:PA5-54656_VPS53_Q5VIR6-4_Rabbit.svg,antigenImageFileNamePDP:PA5-54656_VPS53_Q5VIR6-4_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2649478

Product Specific Information

Immunogen sequence: LRDACLVANI LDPRIKQEII KKFIKQHLSE YLVLFQENQD VAWLDKIDRR YAWIKRQLVD YEEKYGRMFP REWCMAERIA VEFCHVTRAE LAKIMRTRAK EIEVKLL

Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 94%.

Target Information

The sorting of acid hydrolases to lysosomes rely on mannose 6-phosphate receptors that cycle between the trans-Golgi network (TGN) and endosomes. The maintenance of this cycle requires the function of the mammalian Golgi-associated retrograde protein (GARP) complex which is composed of three subunits: VPS52, VPS53, and VPS54. Depletion of any of these three proteins, such as by RNAi, impairs the retrograde transport of multiple TGN proteins. VPS53 was identified as an HIV dependency factor (HDF) and plays a role in viral entry to the cell, suggesting that VPS53 may be an important drug target in HIV treatment. At least five isoforms of VPS53 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.