Thermo Fisher Scientific CDKN2A (p16INK4a) Monoclonal Antibody (OTI1D3), TrueMAB
CDKN2A(p16INK4a) 단백질을 인식하는 mouse monoclonal antibody. Western blot에 최적화된 TrueMAB 포맷. Human 시료 반응성. Affinity chromatography로 정제되어 높은 특이성과 재현성 제공. -20°C에서 보관.
- 카탈로그번호
- TA802963
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
- Western Blot (WB): 1:200–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1D3 |
| Immunogen | Full length human recombinant protein of human CDKN2A produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The CDKN2A gene produces several transcript variants differing in their first exons. At least three alternatively spliced variants encode distinct proteins, two of which act as inhibitors of CDK4 kinase. Another variant encodes the ARF protein, which stabilizes the tumor suppressor p53 by binding and sequestering MDM2, preventing p53 degradation. Despite structural and functional differences, both CDK inhibitor isoforms and the ARF product contribute to G1 cell cycle control. Mutations or deletions in this gene are common in many tumors, underscoring its role as a critical tumor suppressor gene.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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