Thermo Fisher Scientific NMT2 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Purity is > 95% by SDS-PAGE.

Target Information

Proteolytic degradation is critical to maintaining appropriate levels of short-lived and regulatory proteins involved in cellular metabolism, stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signaling.
The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cytosol and nucleus, while others are degraded via the vacuolar pathway (endosomes, lysosomes, and endoplasmic reticulum).
The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular complex (~2.5 MDa), consisting of a 20S proteolytic core and 19S regulatory subunits. These subunits recognize ubiquitinated proteins and facilitate unfolding and translocation into the 20S lumen.
An enzymatic cascade attaches multiple ubiquitin molecules to lysine residues of target proteins. Defects in this pathway are linked to genetic diseases such as cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.