Thermo Fisher Scientific SGPL1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

Immunocytochemistry (ICC/IF)

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 60-390 of human SGPL1 (NP_0038922) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SGPL1,uniProtId:O95470-1,ncbiNodeId:9606,antigenRange:60-390,antigenLength:568,antigenImageFileName:PA5-90667_SGPL1_O95470-1_Rabbit.svg,antigenImageFileNamePDP:PA5-90667_SGPL1_O95470-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.37 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2806168

Product Specific Information

Immunogen sequence: VFQPESLWSR FKKKCFKLTR KMPIIGRKIQ DKLNKTKDDI SKNMSFLKVD KEYVKALPSQ GLSSSAVLEK LKEYSSMDAF WQEGRASGTV YSGEEKLTEL LVKAYGDFAW SNPLHPDIFP GLRKIEAEIV RIACSLFNGG PDSCGCVTSG GTESILMACK AYRDLAFEKG IKTPEIVAPQ SAHAAFNKAA SYFGMKIVRV PLTKMMEVDV RAMRRAISRN TAMLVCSTPQ FPHGVIDPVP EVAKLAVKYK IPLHVDACLG GFLIVFMEKA GYPLEHPFDF RVKGVTSISA DTHKYGYAPK GSSLVLYSDK KYRNYQFFVD TDWQGGIYAS P; Positive Samples: U-87MG, LO2, 293T, A-431, Mouse liver, Mouse kidnay, Mouse lung, Rat brain ; Cellular Location: Endoplasmic reticulum membrane, Single-pass type III membrane protein

Target Information

Sphingosine-1-phosphate lyase cleaves phosphorylated sphingoid bases, such as sphingosine-1 phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. The catalytic activity of sphingosine 1- phosphate lyase converts sphingosine 1-phosphate to phosphoethanolamine and palmitaldehyde using Pyridoxal phosphate as a co-factor. Sphingosine 1-phosphate lyase is a type III membrane protein found in the endoplasmic reticulum. Sphingosine 1-phosphate lyase is found primarily in the liver and kidney. Sphingosine 1-phosphate lyase belongs to the group II decarboxylase family.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.