Thermo Fisher Scientific SMO Monoclonal Antibody (1D9)
SMO 단백질을 인식하는 Thermo Fisher Scientific의 1D9 단클론 항체. Western blot 및 ELISA에 적합. 인간 유래 단백질에 반응하며, PBS(pH 7.4) 용액 형태로 제공. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1D9 |
| Immunogen | SMO (NP_005622.1, 653–787 a.a.) full-length recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein Sequence:
NLWLVEAEIS PELQKRLGRK KKRRKRKKEV CPLAPPPELH PPAPAPSTIP RLPQLPRQKC LVAAGAWGAG DSCRQGAWTL VSNPFCPEPS PPQDPFLPSA PAPVAWAHGR RQGLGPIHSR TNLMDTELMD ADSDF
Target Information
Smoothened drosophila homolog (SMOH) is a serpentine protein belonging to the G-protein coupled receptor Fz/Smo family with 787 amino acids. It contains seven transmembrane domains, four glycosylation sites, and a putative extracellular amino terminus.
Smoothened, activated by β-Arrestin 2 and GRK2, acts as a receptor for Sonic hedgehog (Shh) and positively regulates the hedgehog signaling pathway along with the patched (PTCH) protein. It plays a key role in vertebrate development, cellular proliferation, and differentiation through Gli transcription factor activation.
Mutations in Smoothened are associated with sporadic basal cell carcinoma of the skin. Expression is observed widely in heart and brain tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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