Thermo Fisher Scientific SNAI1 Polyclonal Antibody, MaxPab
SNAI1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 적합합니다. Human 시료에 반응하며, Affinity chromatography로 정제되었습니다. E-cadherin 억제 및 EMT 연구에 유용합니다. -20°C 보관, PBS buffer, 무보존제.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | SNAI1 (NP_005976.2, 1–264 a.a.) full-length human protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein Sequence:
MPRSFLVRKP SDPNRKPNYS ELQDSNPEFT FQQPYDQAHL LAAIPPPEIL NPTASLPMLI WDSVLAPQAQ PIAWASLRLQ ESPRVAELTS LSDEDSGKGS QPPSPPSPAP SSFSSTSVSS LEAEAYAAFP GLGQVPKQLA QLSEAKDLQA RKAFNCKYCN KEYLSLGALK MHIRSHTLPC VCGTCGKAFS RPWLLQGHVR THTGEKPFSC PHCSRAFADR SNLRAHLQTH SDVKKYQCQA CARTFSRMSL LHKHQESGCS GCPR
Target Information
Zinc finger protein SNAI1 (SNAIL) is a zinc finger transcriptional repressor that downregulates ectodermal gene expression within the mesoderm and is essential for mesoderm and neural crest formation.
SNAI1 plays a critical role in tumor invasion by mediating E-cadherin down-regulation and epithelial-mesenchymal transition (EMT).
In human breast cancer, SNAI1 and/or SNAI2 (Slug) expression is associated with E-cadherin repression, metastasis, recurrence, and poor prognosis.
Snail 1 protein in the stroma may serve as a novel prognostic marker for colon tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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