Thermo Fisher Scientific Human Activin A Recombinant Protein

Applications

Western Blot (WB)

• Assay-dependent

Control (Ctrl)

• Assay-dependent

Product Specifications

Product Specific Information

RP-75636 contains a purified 116 amino acid fragment (aa311–426) of mature human Inhibin beta A chain protein with an N-terminal hexahistidine tag.
This product may be used as a positive control in various immunological assays.

Target Information

Activins are dimeric growth and differentiation factors belonging to the transforming growth factor-beta (TGF-β) superfamily of structurally related signaling proteins.
They signal through a heteromeric complex of receptor serine kinases, including at least two type I (I and IB) and two type II (II and IIB) receptors.
These receptors are transmembrane proteins with:

• A ligand-binding extracellular domain containing cysteine-rich regions
• A transmembrane domain
• A cytoplasmic domain with predicted serine/threonine kinase specificity

Type I receptors are essential for signaling, while type II receptors are required for ligand binding and expression of type I receptors. Upon ligand binding, type I and II receptors form a stable complex, leading to phosphorylation of type I receptors by type II receptors.
Mutations in Activin A are associated with fibrodysplasia ossificans progressiva.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.