Thermo Fisher Scientific Estrogen Receptor alpha Monoclonal Antibody (6F11)
에스트로겐 수용체 알파(ERα)를 인식하는 단클론 항체로 인간, 마우스, 랫트 반응성. WB, IHC, ICC 등 다양한 응용 가능. 파라핀 절편은 항원 회복 처리 필요. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:50 | View 3 publications |
| Immunohistochemistry (IHC) | - | View 24 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:40–1:80 | View 8 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:40–1:60 | - |
| Immunocytochemistry (ICC/IF) | 1:100 | View 1 publication |
| ChIP assay (ChIP) | 5 µL/10^6 cells | - |
| Gel Shift (GS) | - | View 1 publication |
Product Specifications
| Category | Specification |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Cat, Human, Mouse, Rabbit, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6F11 |
| Immunogen | Recombinant estrogen receptor protein (alpha form) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Purification | Purified |
| Storage Buffer | Tissue culture supernatant |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_780508 |
Product Specific Information
- Paraffin sections require antigen retrieval pretreatment with sodium citrate buffer (pH 6.0) prior to staining.
- Use Samboni’s fixative for optimal staining results.
- Positive control: Breast carcinoma.
Target Information
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor that, when bound to estrogen, undergoes a conformational change allowing dimerization and binding to estrogen response elements (ERE) in DNA. This interaction regulates gene transcription through coactivator or corepressor recruitment.
There are two forms of estrogen receptor, alpha (ESR1) and beta (ESR2), encoded by separate genes. At least four estrogen receptor-alpha isoforms are known (Isoform 1: 66 kDa, Isoform 2: 53 kDa, Isoform 3: 47 kDa, Isoform 4: 35 kDa). Estrogen receptors are widely expressed in various tissues and are essential for sexual development, reproductive function, and bone health. They are implicated in pathological conditions such as breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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