Thermo Fisher Scientific APP Monoclonal Antibody (OTI1E6), TrueMAB
인간 APP 단백질을 인식하는 마우스 모노클로날 항체로, Western blot 및 Immunocytochemistry에 적합합니다. 동결건조 형태이며 1 mg/mL 농도로 제공됩니다. 알츠하이머병 관련 연구 및 단백질 발현 분석에 활용 가능합니다.
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Thermo Fisher Scientific APP Monoclonal Antibody (OTI1E6), TrueMAB
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1E6 |
| Immunogen | Full-length human recombinant APP protein produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final concentration of approximately 1 mg/mL.
For conjugation experiments, perform desalting using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Amyloid Precursor Protein (APP) functions as a cell surface kinesin I membrane receptor, mediating axonal transport of beta-secretase and presenilin 1.
APP is essential for neurite growth, neuronal adhesion, and axonogenesis. It is a 100–140 kDa transmembrane glycoprotein that exists in multiple isoforms due to alternative splicing.
Proteolytic cleavage of APP by beta- and gamma-secretases generates beta amyloid, the main component of senile plaques — a hallmark of Alzheimer’s disease.
Abnormal APP processing is also implicated in Down’s syndrome, familial Alzheimer’s disease, and cerebral hemorrhage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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