Thermo Fisher Scientific BRAF Polyclonal Antibody
BRAF 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC 및 IHC(P) 실험에 적합합니다. Human에 반응하며, Mouse, Rat 등에서도 예측 반응합니다. 항원 친화 크로마토그래피로 정제되었으며 4°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: 1:100–1:500
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 25 and 75 of human v-raf murine sarcoma viral oncogene homolog B1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, predicted to react with Mouse, Rat, Bovine, Dog, Gorilla, Chimpanzee, Northern white-cheeked gibbon, Small-eared galago, and Crab-eating macaque
Target Information
BRAF is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. It is activated by somatic point mutation in human cancer and is thought to play a role in postsynaptic responses of hippocampal neurons. This protein regulates the MAP kinase/ERKs signaling pathway, influencing cell division, differentiation, and secretion.
Mutations in B-Raf have been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and lung adenocarcinoma.
A pseudogene for B-Raf has been identified on chromosome X.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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