Thermo Fisher Scientific Mouse IL-12 p80 Recombinant Protein, PeproTech

Applications

Tested Dilution

Publications

Functional Assay (Functional)

Assay-dependent

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Miscellaneous PubMed (Misc)

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View 1 publication 1 publication

Product Specifications

Species

Mouse

Published species

Mouse

Expression System

HEK293 cells

Amino acid sequence

p40 subunit: MWELEKDVYV VEVDWTPDAP GETVNLTCDT PEEDDITWTS DQRHGVIGSG KTLTITVKEF LDAGQYTCHK GGETLSHSHL LLHKKENGIW STEILKNFKN KTFLKCEAPN YSGRFTCSWL VQRNMDLKFN IKSSSSSPDS RAVTCGMASL SAEKVTLDQR DYEKYSVSCQ EDVTCPTAEE TLPIELALEA RQQNKYENYS TSFFIRDIIK PDPPKNLQMK PLKNSQVEVS WEYPDSWSTP HSYFSLKFFV RIQRKKEKMK ETEEGCNQKG AFLVEKTSTE VQCKGGNVCV QAQDRYYNSS CSKWACVPCR VRS

Molecular weight

80 kDa

Class

Recombinant

Type

Protein

Purity

≥ 95% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

Determined by its ability to inhibit the proliferative effect of 2 ng/ml mIL-12 p70 in T cell-enriched PBMCs.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Product Specific Information

210-12P80H-100UG will be provided as 2 x 50 µg (210-12P80H-50UG).

210-12P80H-1MG will be provided as 20 x 50 µg (210-12P80H-50UG).

210-12P80H-250UG will be provided as 5 x 50 µg (210-12P80H-50UG).

210-12P80H-500UG will be provided as 5 x 100 µg (210-12P80H-50UG).

Recombinant Murine IL-12 p80 is an 80.0 kDa, disulfide linked homodimer of two p40 chains of IL-12 that consists of 626 amino acid residues and less than 5% of the IL-12 p40 monomer.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

IL-12 is a disulfide-linked heterodimeric protein (p70), composed of two subunits, p35 and p40, which are encoded by two different genes. Accumulating data indicates that p40 secretion precedes that of IL-12 expression. In addition, to its ability to covalently bind to p35 to form IL-12, p40 can bind to p19 to form IL-23, or it can form the homodimer designated IL-12 p80. Elevated levels of IL-12 p80 correlate to macrophage recruitment and increased inflammation in asthma and respiratory viral infection models.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.