Thermo Fisher Scientific IL-22 Receptor alpha Monoclonal Antibody (496514)
IL-22 수용체 알파에 특이적인 Rat monoclonal antibody로, ICC/IF 및 유세포분석에 적합합니다. 인간 IL-22Rα1과 25% 교차반응을 보이며, 동결건조 형태로 제공됩니다. JAK-STAT 신호전달 연구 및 염증 반응 연구에 활용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 8–25 µg/mL |
| Flow Cytometry (Flow) | 2.5 µg / 1×10⁶ cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rat / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 496514 |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant mouse IL-22 R alpha 1 (Thr18–Ala228) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2607024 |
Product Specific Information
- In direct ELISAs, 25% cross-reactivity with recombinant human (rh) IL-22 R alpha 1 is observed.
- No cross-reactivity with rhIL-20 R alpha, recombinant mouse (rm) IL-20 R alpha, rhIL-22BP, or rmIL-22BP is observed.
- Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
IL-22 (also known as IL-TIF, IL-10 related T cell-derived inducible factor) is a novel cytokine whose receptor, IL-22R (also termed CRF2-9 or IL-TIF-R1 chain), belongs to the class II cytokine receptor family.
IL-22R forms a complex with IL-10 receptor beta chain to mediate IL-22 signaling via the JAK-STAT pathway.
IL-22R is expressed in normal liver and kidney, as well as in cell lines HepG2 and TK-10.
A soluble form of IL-22 receptor, IL-22 binding protein (IL-22BP or IL-22RA2), was recently identified. IL-22BP prevents IL-22 from binding to the functional IL-22R complex, thereby neutralizing IL-22 activity.
LPS induces IL-22 expression, indicating its role in the inflammatory response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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