Thermo Fisher Scientific CD274 (PD-L1, B7-H1) Monoclonal Antibody (MIH5), Alexa Fluor 660, eBioscience
마우스 PD-L1(B7-H1)을 인식하는 MIH5 클론의 Alexa Fluor 660 결합 단클론 항체. Flow cytometry에 최적화되어 있으며, 0.125 µg/test로 사용 가능. 적색 레이저(662 nm)에서 여기되어 690 nm에서 방출. 4°C 보관, 동결 금지.
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Thermo Fisher Scientific CD274 (PD-L1, B7-H1) Monoclonal Antibody (MIH5), Alexa Fluor 660, eBioscience
Applications
- Flow Cytometry (Flow)
Tested Dilution: 0.125 µg/test
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host/Isotype | Rat / IgG2a, lambda |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), Alexa Fluor™ 660, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MIH5 |
| Conjugate | Alexa Fluor™ 660 |
| Excitation/Emission Max | 663 / 691 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2896297 |
Additional Formats
- Unconjugated
- Alexa Fluor 488
- APC
- Biotin
- Brilliant UV 615
- Brilliant UV 661
- Brilliant UV 737
- Brilliant UV 805
- Brilliant Violet 421
- Brilliant Violet 650
- Brilliant Violet 786
- Functional Grade
- NovaFluor Red 700
- NovaFluor Red 755
- NovaFluor Yellow 690
- NovaFluor Yellow 700
- PE
- PE-Cyanine7
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Super Bright 645
- Super Bright 780
- Request custom conjugation
Product Specific Information
The MIH5 monoclonal antibody reacts with mouse B7-H1, also known as PD-L1. B7-H1 is a member of the B7 family with a molecular weight of approximately 40 kDa and belongs to the Ig superfamily. It is expressed on T, B, NK, and DC cells and acts as a ligand for PD-1. The interaction between PD-1 and PD-L1 or PD-L2 inhibits T and B cell responses. MIH5 is reported to be a blocking antibody.
Applications Reported:
Used in flow cytometric analysis.
Applications Tested:
Tested by flow cytometric analysis of mouse splenocytes. Recommended use ≤ 0.125 µg/test (100 µL final volume). Optimal titration is advised for best assay performance.
Fluorophore Characteristics:
Alexa Fluor 660 emits at 690 nm and is suitable for spectral cytometers.
Excitation: 662 nm; Emission: 690 nm; Laser: Red Laser.
Target Information
Programmed death receptor ligand 1 (PD-L1, B7-H1) is a B7 family member that binds PD-1, negatively regulating T-cell receptor signaling. PD-L1 reduces TCR-mediated proliferation and cytokine production. Expression is abundant on murine and human cancers and can be upregulated by IFN-γ, suggesting a role in tumor immune evasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without authorization.
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