Thermo Fisher Scientific IRF4 Monoclonal Antibody (A7D1)
IRF4 단백질을 인식하는 마우스 단클론 항체로, IHC(P) 실험에 적합합니다. 인간 시료에 반응하며, Protein G 정제 및 PBS 기반 완충용액에 보관됩니다. 단기 4°C, 장기 -20°C에서 안정적으로 저장 가능합니다.
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Applications
Tested Application
- Immunohistochemistry (Paraffin) (IHC (P)): 1:1,500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | A7D1 |
| Immunogen | Synthetic peptide within human MUM1 aa 402–451/451 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol, 0.1% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2931406 |
Target Information
The IRF (interferon regulatory factor) family of transcription factors are characterized by a unique tryptophan pentad repeat DNA-binding domain. The IRFs play a critical role in regulating interferon responses to viral infection and in controlling interferon-inducible gene expression.
IRF4 is lymphocyte-specific and acts as a negative regulator of toll-like receptor (TLR) signaling, which is central to both innate and adaptive immune activation.
A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), is associated with multiple myeloma. Alternatively spliced transcript variants have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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