Thermo Fisher Scientific ALK Monoclonal Antibody (OTI13A1), TrueMAB
Human ALK 단백질에 특이적인 Rat 모노클로날 항체로 Western blot에 적합. TrueMAB 형식으로 1 mg/mL 농도, 액상 상태이며 PBS/BSA/glycerol buffer에 보존. 뇌 발달 관련 연구 및 ALK 관련 종양 연구에 활용 가능.
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rat / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI13A1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1060–1620 of human ALK produced in SF9 cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and is vital for brain development. Mutations, rearrangements, and amplifications in the ALK gene have been found in tumors including anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer.
Chromosomal rearrangement is the most common genetic alteration, creating a fusion gene consisting of the ALK gene and the nucleophosmin (NPM) gene. The product of the NPM-ALK fusion gene is oncogenic.
ALK encodes a receptor protein-tyrosine kinase with transmembrane and extracellular domains, absent in the transforming NPM-ALK gene product. ALK shows high sequence similarity to LTK and plays an important role in brain development, exerting effects on specific neurons in the nervous system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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