Thermo Fisher Scientific NFkB p52 Polyclonal Antibody
NFkB p52 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot 및 IHC(P) 응용에 적합하며, 고순도(>95%) 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로 NFkB 신호전달 및 염증 반응 연구에 활용됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 840–890 of Human NFkB-p100 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2802981 |
Product Specific Information
Purity is >95% by SDS-PAGE.
Target Information
This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB).
NFkB is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function.
The encoded protein can act as both a transcriptional activator or repressor depending on its dimerization partner.
The p100 full-length protein is co-translationally processed into a p52 active form.
Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, potentially forming fusion proteins.
A pseudogene exists on chromosome 18, and alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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