Thermo Fisher Scientific PYCARD Recombinant Rabbit Monoclonal Antibody (3H64L37)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody is predicted to react with Mouse, Rat, and Bovine.

Target Information

PYCARD functions as a key mediator in apoptosis and inflammation. It promotes caspase-mediated apoptosis involving caspase-8 and caspase-9, and is involved in activation of the mitochondrial apoptotic pathway. PYCARD mediates macrophage pyroptosis, forming the ASC pyroptosome upon potassium depletion and activating caspase-1. It acts as an adapter in inflammasome assembly, regulating processing and secretion of proinflammatory cytokines through pyrin and CARD domains. It is required for recruitment of caspase-1 to inflammasomes containing NLRP2, NLRP3, AIM2, and IFI16, and facilitates processing of procaspase-1 in NLRP1 and NLRC4 inflammasomes. Additionally, PYCARD participates in NOD2-related inflammasome activation and may regulate NF-κB signaling. Isoforms 2 and 3 have distinct regulatory roles in inflammasome function. The protein also contributes to adaptive immune responses, dendritic cell maturation, and cytokine transcriptional activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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