Thermo Fisher Scientific PYCARD Recombinant Rabbit Monoclonal Antibody (3H64L37)
Thermo Fisher Scientific의 PYCARD Recombinant Rabbit Monoclonal Antibody (3H64L37)는 인간 PYCARD 단백질을 표적으로 하는 고품질 재조합 단클론 항체입니다. Western blot 및 Immunocytochemistry에 최적화되어 있으며, 단백질 A로 정제된 액상 형태로 제공됩니다. 염증 및 세포사멸 연구용으로 적합합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 3H64L37 |
| Immunogen | Protein corresponding to human PYCARD (aa1–aa110) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2895880 |
Product Specific Information
This antibody is predicted to react with Mouse, Rat, and Bovine.
Target Information
PYCARD functions as a key mediator in apoptosis and inflammation. It promotes caspase-mediated apoptosis involving caspase-8 and caspase-9, and is involved in activation of the mitochondrial apoptotic pathway. PYCARD mediates macrophage pyroptosis, forming the ASC pyroptosome upon potassium depletion and activating caspase-1. It acts as an adapter in inflammasome assembly, regulating processing and secretion of proinflammatory cytokines through pyrin and CARD domains. It is required for recruitment of caspase-1 to inflammasomes containing NLRP2, NLRP3, AIM2, and IFI16, and facilitates processing of procaspase-1 in NLRP1 and NLRC4 inflammasomes. Additionally, PYCARD participates in NOD2-related inflammasome activation and may regulate NF-κB signaling. Isoforms 2 and 3 have distinct regulatory roles in inflammasome function. The protein also contributes to adaptive immune responses, dendritic cell maturation, and cytokine transcriptional activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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