Thermo Fisher Scientific LIMP2 Polyclonal Antibody
Thermo Fisher Scientific의 LIMP2 Polyclonal Antibody는 인간 단백질 SCARB2를 인식하는 염소 유래 다클론 항체입니다. Western blot 및 IHC(P) 실험에 적합하며, 고순도 및 안정적인 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA519111
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–0.3 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3–5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (NKANIQFGDNGTTIS) corresponding to the internal amino acids of SCARB2 (aa 96–111) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_10986986 |
Product Specific Information
- This antibody is predicted to react with mouse based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 4,000.
Target Information
High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis.
SR-BI and SR-BII (previously known as SR-BI.2) are alternatively spliced products of a single gene. SR-BII differs from SR-BI in that the encoded C-terminal cytoplasmic domain is almost completely different.
SR-BII binds HDLs and mediates selective uptake of HDL cholesteryl ester, but with approximately 4-fold lower efficiency than SR-BI.
Nuclease protection assays show SR-BII to be abundant in mouse tissues expressing SR-BI, with SR-BII expression found in liver, adrenal glands, and testes.
Although the role of SR-BII is not completely clear, research suggests that it may be a functional HDL receptor.
SR-BII mRNA results from the alternative splicing of SR-BI precursor transcripts, with the SR-BII isoform mediating selective transfer of lipid between HDL and cells.
The relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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