Thermo Fisher Scientific Calpain 3 Polyclonal Antibody
Calpain 3 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC, Flow Cytometry에 사용 가능. 인간 시료에 반응하며, 근육 단백질 분해 및 세포골격 재조직 연구에 적합. 2 mg/mL 농도의 액상 형태로 제공.
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Flow Cytometry (Flow) | 1:10–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 603–632 of the C-terminal region of human CAPN3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Ammonium sulfate precipitation, Size-exclusion, Dialysis |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2544318 |
Product Specific Information
This antibody is predicted to react with non-human primate based on sequence homology.
Target Information
Calpain is an intracellular calcium-dependent protease involved in cleavage of cytoskeletal and submembranous proteins, contributing to cytoskeletal reorganization and muscle protein degradation. It is a heterodimer composed of a small regulatory subunit and one of three large catalytic subunits: calpain 1, calpain 2, and calpain 3.
Calpain 3 (also known as calpain p94) is a muscle-preferred, calcium-activated neutral protease that localizes to the nucleus. Mutations in the calpain 3 gene are associated with limb-girdle muscular dystrophy type 2A, an autosomal recessive neuromuscular disorder. Calpastatin regulates calpain activity by inhibiting both its proteolytic function and membrane binding. Two types of calpastatin exist—tissue type and erythrocyte type—arising from alternative splicing and proteolytic processing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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