Thermo Fisher Scientific PI3K p85 alpha Polyclonal Antibody
PI3K p85 alpha 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, IHC(P), ICC/IF에 적합합니다. Human 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 연구용으로 신호전달 및 인슐린 관련 연구에 활용됩니다.
- 카탈로그번호
- PA5110625
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PI3K p85 alpha. Recombinant protein control fragment (Product #RP-95921). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2856036 |
Product Specific Information
Immunogen sequence:
LADAFKRYLL DLPNPVIPAA VYSEMISLAP EVQSSEEYIQ LLKKLIRSPS IPHQYWLTLQ YLLKHFFKLS QTSSKNLLNA RVLSEIFSPM LFRFSAASSD NTENLIKVIE ILISTEWNER QPAPALPPKP PKPTTVANNG MNNNMSL
Target Information
Phosphatidylinositol 3-kinase (PIK3) is a signaling protein that phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. Signaling is initiated when upstream tyrosine kinase receptors or G protein-coupled receptors are bound by their ligands. It binds to activated (phosphorylated) protein-Tyr kinases through its SH2 domain and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.
Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and mutations in this gene have been associated with insulin resistance. During insulin stimulation, it also binds to IRS-1. Mutations in the gene can result in Agammaglobulinemia 7, SHORT syndrome, or Immunodeficiency 36.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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