Thermo Fisher Scientific CD11c Monoclonal Antibody (CBR-p150/4G1), eBioscience

Applications

Tested Dilution

Publications

Immunohistochemistry (IHC)

Assay-Dependent

-

Flow Cytometry (Flow)

Assay-Dependent

-

Functional Assay (Functional)

Assay-Dependent

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a

Class

Monoclonal

Type

Antibody

Clone

CBR-p150/4G1

Immunogen

Rec. Human Podoplanin

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS

Contains

no preservative

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10597453

Product Specific Information

Description: BMS112 detects CD11c from human samples. Integrin alpha X (CBR-p150/4G1) is a mouse monoclonal antibody raised againstIntegrin alpha X of human origin.

The antibody can be used to stain aceton-fixed cryostat sections or cell smears. BMS112 is also suitable as primary antibody in immunofluorescence, flow cytometry. In functional assays the antibody inhibits binding between p150,95 and endothelial cells.

CD11c non-covalently associates with beta2 integrin to form the CD11c/CD18 heterodimer. This complex is expressed on monocytes, granulocytes, macrophages, NK, dendritic cells and subset of T and B lymphocytes. CD11c/CD18 binds to CD54, iC3b and fibrinogen and plays a role in leukocyte adhesive interactions.

Applications Tested: Flow Cytometry, Functional Studies (Blocking), Immunohistochemistry (Frozen).

Purity: >95%.

Target Information

CD11, along with CD18, form a heterodimer adhesion molecule. In particular, CD11 is composed of CD11a, CD11b and CD11c. CD11a is a leukocyte marker that is expressed in B and T lymphocytes, macrophages, monocytes, neutrophils, basophils and eosinophils. CD11b is primarily expressed by monocytes, macrophages, natural killer cells, some B and T-cells, and granulocytes. CD11c is expressed in monocytes, macrophages, natural killer cells, some granulocytes and less so in a subset of lymphocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.