Thermo Fisher Scientific Phospho-Aconitase 1 (Ser138) Polyclonal Antibody
인산화된 Aconitase 1 (Ser138)을 인식하는 Rabbit Polyclonal 항체로, 세포 내 철 항상성 연구에 적합합니다. IHC(P)에서 1:50~1:100 희석 비율로 사용되며, 액상 형태로 -20°C 보관합니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA538637
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphopeptide derived from human IREB1 around the phosphorylation site of Ser138 (A-D-SP-L-Q) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2555232 |
Target Information
Aconitase 1 (ACO1), also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein that binds to iron-responsive elements (IREs).
It plays a central role in cellular iron homeostasis and exhibits aconitase activity, classifying it within the aconitase enzyme family.
IREs are stem-loop structures located in the 5′ UTR of ferritin mRNA and the 3′ UTR of transferrin receptor mRNA. Iron-induced binding to IREs represses ferritin translation and stabilizes transferrin receptor mRNA, thereby regulating intracellular iron levels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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