Thermo Fisher Scientific ALX3 Polyclonal Antibody
ALX3 단백질을 검출하기 위한 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF 등 다양한 응용에 적합. 인간, 마우스, 랫트 반응성. Affinity chromatography로 정제된 액상 형태. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ALX3 (Accession O95076), corresponding to amino acid residues Q185–R235 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850520 |
Product Specific Information
Antibody detects endogenous levels of total ALX3.
Target Information
Aristaless-related genes are a group of paired-related homeobox genes involved in vertebrate embryogenesis regulation.
The homeodomain transcription factor aristaless-like 3 (ALX3) is expressed in mouse embryos from 8 days of gestation, mainly in neural crest-derived mesenchyme and lateral plate mesoderm.
Human and mouse tissue analysis shows predominant ALX3 expression in brain tissue.
The Alx3 gene maps to chromosome 1p23-p13 and encodes a 343 amino acid protein. Preferential methylation of Alx3 occurs in advanced-stage neuroblastoma and may repress ALX3 expression.
Treatment with the methylation inhibitor 5-aza-2’-deoxycytidine restores ALX3 expression.
Alx3 (-) mice show no distinct phenotype compared to wild-type, but Alx3/Alx4 double mutants exhibit severe craniofacial abnormalities not seen in Alx4 single mutants, including cleft nasal regions and malformations of neural crest-derived skull structures.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-101076_ALX3_O95076-1_Rabbit.svg, PA5-101076_ALX3_O95076-1_Rabbit_PDP.jpeg)
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