Thermo Fisher Scientific LRAT Polyclonal Antibody
LRAT 단백질을 검출하기 위한 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. WB, IHC, ICC/IF 등 다양한 응용에 적합. Human, Mouse, Rat 반응성. 고순도 Affinity chromatography 정제, -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human LRAT (Accession O95237), corresponding to amino acid residues Y118–C168 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2850521 |
Product Specific Information
Antibody detects endogenous levels of total LRAT.
Target Information
Lecithin retinol acyltransferase (LRAT) is a membrane-bound enzyme that catalyzes the transfer of an acyl group from the sn-1 position of lecithin to vitamin A, generating all-trans-retinyl esters (tREs) in the liver and other tissues such as lung and retinal pigmented epithelium.
LRAT also exchanges palmitoyl groups between RPE65 and tREs, which is vital for the visual pathway. It plays an essential role in vitamin A mobilization, transport, and storage, as well as synthesis of the visual pigment chromophore.
Loss of LRAT correlates with early-onset severe retinal dystrophy and retinyl ester deprivation, while reduced LRAT expression may be associated with invasive bladder cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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