Thermo Fisher Scientific SNAI2 Monoclonal Antibody (OTI2A6), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Flow Cytometry (Flow)

• Tested Dilution: 1:100

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, is involved in epithelial-mesenchymal transitions and neural tube formation during vertebrate embryogenesis. Its transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Slug binds E-box regions of promoters to repress transcription of genes like E-cadherin and Claudin-1.
Expression of Slug in breast, esophageal, and colorectal carcinomas correlates with poor prognosis. It also protects hematopoietic progenitor cells from radiation-induced apoptosis by repressing p53-mediated transcription of Puma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.