Thermo Fisher Scientific Cathepsin A Polyclonal Antibody
인간 Cathepsin A를 인식하는 Rabbit Polyclonal 항체로, WB, IHC(P), ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관. 단기 4°C, 장기 -20°C 저장 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human Cathepsin A. Recombinant protein control fragment (Product #RP-102373) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2639312 |
Product Specific Information
Immunogen sequence:
PCTNTTAAST YLNNPYVRKA LNIPEQLPQW DMCNFLVNLQ YRRLYRSMNS QYLKLLSSQK YQILLYNGDV DMACNFMGDE WFVDSLNQKM EVQRRPWLVK YGDSGEQIAG FVKEFSHIAF LTIKGAGHMV PTDKPLAA
Antigen sequence identity:
- Mouse: 91%
- Rat: 61%
Target Information
The cathepsin family of proteolytic enzymes includes several diverse classes of proteases. Cathepsins B, L, H, K, S, and O comprise the cysteine protease class. Cathepsins D and E comprise the aspartyl protease class, while cathepsin G is a serine protease. Cathepsins function in cellular metabolism and participate in peptide biosynthesis and protein degradation.
Cathepsin A, a serine carboxypeptidase, exists in a high molecular weight lysosomal complex with β-galactosidase (β-gal) and α-neuraminidase (Neu1). It functions to protect β-gal and Neu1 from intralysosomal proteolysis. Deficiencies in cathepsin A lead to deficiencies in β-gal and Neu1. The gene encoding human cathepsin A maps to chromosome 20q13.12. Mutations in this gene cause galactosialidosis, a lysosomal storage disorder resulting from β-gal and Neu1 deficiencies.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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