Thermo Fisher Scientific LGR5 Recombinant Rabbit Monoclonal Antibody (4H8)
LGR5 단백질을 인식하는 토끼 유래 재조합 단클론 항체로, Western blot과 유세포분석에 사용 가능. 인간 및 랫트 시료에 반응하며, 고순도 친화크로마토그래피 정제. PBS/glycerol 완충액 형태로 -20°C 이하 보관.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific LGR5 Recombinant Rabbit Monoclonal Antibody (4H8)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:5,000 |
| Flow Cytometry (Flow) | 1:20–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 4H8 |
| Immunogen | A synthesized peptide derived from human LGR5/GPR49 (amino acids 836–851, UniProt ID: O75473-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 150 mM NaCl |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_2898250 |
Product Specific Information
This antibody has been tested in direct-ELISA.
Target Information
G protein-coupled receptor GPR49 (LGR5) is expressed in brain, skeletal muscle, placenta, and spinal cord. ESTs have been isolated from normal human brain (amygdala), embryo, and placenta libraries, as well as from human germ cell, uterus, and brain libraries.
G-protein Coupled Receptors (GPCRs) represent one of the largest families of signaling molecules, with over a thousand predicted members. They share a structural motif of seven membrane-spanning helices and exist in both active and inactive forms. Ligand binding induces conformational changes that activate G-proteins and downstream signaling pathways.
Regulatory mechanisms that “turn off” GPCR signaling are crucial for cellular physiology and are key targets in pharmacological research. Notably, GPCR-targeted drugs such as Zyprexa (Eli Lilly) and Claritin (Schering-Plough) have achieved significant success in mental health and allergy treatment markets.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.