Thermo Fisher Scientific CD42b Polyclonal Antibody

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:50–1:100

Product Specifications

Product Specific Information

Immunogen sequence:
ICEVSKVASH LEVNCDKRNL TALPPDLPKD TTILHLSENL LYTFSLATLM PYTRLTQLNL DRCELTKLQV DGTLPVLGTL DLSHNQLQSL PLLGQTLPAL TVLDVSFNRL TSLPLGALRG LGELQELYLK GNELKTLPPG LLTPTPKLEK LSLANNNLTE LPAGLLNGLE NLDTLLLQEN SLYTIPKGFF GSHLLPFAFL HGNPWLCNCE ILYFRRWLQD NAENVYVWKQ GVDVKAMTSN V

Positive Samples: Jurkat, K-562
Cellular Location: Membrane, Single-pass type I membrane protein

Target Information

CD42b is a platelet activation marker involved in the coagulation process as an aggregating factor. It interacts with extracellular matrix and adhesion molecules. CD42b expression and activation are regulated by VEGF and PDGF.
CD42b forms part of the GPIb-IX-V receptor complex (with GPIb beta, GPIX, and GPV), essential for platelet-rich thrombus formation by tethering platelets to thrombogenic surfaces.
It binds von Willebrand factor (VWF) at vascular injury sites, as well as thrombin, coagulation factors XI and XII, high molecular weight kininogen, TSP-1, integrin Mac-1, and P-selectin.
The extracellular domain contributes to metastasis, and CD42b antigen is expressed on platelets and bone marrow megakaryocytes.
Several polymorphisms and mutations in CD42b are associated with Bernard-Soulier syndromes and platelet-type von Willebrand disease.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.