Thermo Fisher Scientific CD42b Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunocytochemistry (ICC/IF)

1:50-1:100

-

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 19-259 of human GP1BA if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CD42b,uniProtId:P07359-1,ncbiNodeId:9606,antigenRange:19-259,antigenLength:652,antigenImageFileName:PA5-90903_CD42b_P07359-1_Rabbit.svg,antigenImageFileNamePDP:PA5-90903_CD42b_P07359-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.96 mg/mL

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2806283

Product Specific Information

Immunogen sequence: ICEVSKVASH LEVNCDKRNL TALPPDLPKD TTILHLSENL LYTFSLATLM PYTRLTQLNL DRCELTKLQV DGTLPVLGTL DLSHNQLQSL PLLGQTLPAL TVLDVSFNRL TSLPLGALRG LGELQELYLK GNELKTLPPG LLTPTPKLEK LSLANNNLTE LPAGLLNGLE NLDTLLLQEN SLYTIPKGFF GSHLLPFAFL HGNPWLCNCE ILYFRRWLQD NAENVYVWKQ GVDVKAMTSN V; Positive Samples: Jurkat, K-562; Cellular Location: Membrane, Single-pass type I membrane protein

Target Information

CD42b is a platelet activation marker involved in the process of coagulation as an aggregating factor. It interacts with extracellular matrix as well as with adhesion molecules. CD42b expression and activation seems to be regulated by VEGF and PDGF. CD42b composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis. Further, CD42b antigen is expressed on platelets and on megakaryocytes in bone marrow. Several polymorphisms and mutations have been described in the CD42b, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.