Thermo Fisher Scientific IL-17A Monoclonal Antibody (eBio64DEC17), FITC, eBioscience
인간 IL-17A를 인식하는 중화 모노클로날 항체로, FITC로 표지되어 세포내 염색 및 유세포분석에 최적화됨. 염증 반응 연구 및 Th17 세포 분석에 활용 가능. Blue Laser(488 nm) 기반 형광 검출에 적합하며, 4°C 암조건 보관.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | 3 |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | 1 |
| Immunocytochemistry (ICC/IF) | - | 4 |
| Flow Cytometry (Flow) | 5 µL (0.125 µg)/test | 38 |
| ELISA | - | 5 |
| Neutralization | - | 2 |
| Radioimmune Assays (RIA) | - | 1 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Hamster, Human, Rat, Rhesus monkey |
| Host/Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), FITC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBio64DEC17 |
| Conjugate | FITC |
| Excitation/Emission Max | 498/517 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10805390 |
Additional Formats
- Unconjugated
- Alexa Fluor 488
- APC
- APC-eFluor 780
- Biotin
- Brilliant UV 563
- Brilliant UV 737
- Brilliant UV 805
- Brilliant Violet 605
- Brilliant Violet 786
- eFluor 450
- eFluor 506
- eFluor 660
- PE
- PE-Cyanine7
- PE-eFluor 610
- PerCP-Cyanine5.5
- Request custom conjugation
Product Specific Information
The eBio64DEC17 antibody reacts with human IL-17A and functions as a neutralizing antibody. IL-17A is a CD4+ T cell-derived cytokine involved in promoting inflammatory responses and is elevated in diseases such as rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection. It exists as a glycosylated 20–30 kDa homodimer and is produced by activated peripheral blood CD4+ T cells.
IL-17A enhances expression of ICAM-1 in fibroblasts and stimulates epithelial, endothelial, and fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. It also supports proliferation of CD34+ hematopoietic progenitors and their maturation into neutrophils. Mouse, rat, and human IL-17A all induce IL-6 secretion in mouse stromal cells, indicating cross-species receptor recognition.
IL-23-dependent, IL-17A-producing CD4+ T cells (Th17 cells) represent a distinct subset of helper T cells, negatively regulated by Th1 and Th2 cytokines (e.g., IFN-γ, IL-4).
Intracellular staining with eBio64DEC17 identifies the same population as eBio64CAP17.
Applications Reported: Intracellular staining and flow cytometric analysis.
Applications Tested: Pre-titrated for intracellular staining of stimulated human peripheral blood cells. Recommended use: 5 µL (0.125 µg) per test in 100 µL final volume.
Excitation/Emission: 488/520 nm (Blue Laser).
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
Interleukin-17A (IL-17A, CTLA-8) is a 32 kDa disulfide-linked homodimer of 136 amino acids, part of the IL-17 family (IL-17A–F). It signals through IL-17R/CDw217 and regulates NF-κB and MAPK pathways, stimulating IL-6 and COX-2 expression and enhancing nitric oxide production. IL-17A plays a key role in inflammatory and autoimmune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without authorization.
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