Thermo Fisher Scientific G-CSF Monoclonal Antibody (KT27)

Applications

• Western Blot (WB): 1:1,000
• Indirect ELISA: 사용됨 (Product Specific Information 참조)

Product Specifications

Product Specific Information

This product was used in an Indirect ELISA.

Target Information

G-CSF (Granulocyte Colony Stimulating Factor) is a naturally occurring cytokine that stimulates the production and antibacterial function of neutrophils and monocytes. Human G-CSF is an 18.8 kDa protein containing 175 amino acid residues, and a soluble isoform of the G-CSF receptor has been described.

This pleiotropic cytokine is produced by activated monocytes, macrophages, endothelial cells, fibroblasts, astrocytes, osteoblasts, and bone marrow cells. G-CSF has specific effects on the proliferation, differentiation, and activation of hematopoietic cells. It is also expressed by various transformed cells such as carcinoma cells and myeloblastic leukemia cells.

G-CSF is encoded by two distinct DNA sequences, resulting in a full-size, high-activity isoform and a shorter, low-activity isoform. It is highly conserved among species and exerts its biological functions through interaction with its receptor expressed on hematopoietic progenitors, neutrophilic granulocytes, and certain carcinoma cell lines.

Clinical relevance: G-CSF has been approved for therapeutic applications including treatment of neonatal infections, acute myocardial infarction, neutropenia, severe infections, sepsis, chronic autoimmune neutropenia, acute myeloid leukemias, Sweet’s syndrome, and AIDS. It is also a marker protein for various carcinomas such as bladder cancer, and dysfunction of G-CSF has been linked to Kostmann Syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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