Thermo Fisher Scientific TMEM110 Polyclonal Antibody
TMEM110 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P) 및 ICC/IF에 사용 가능. 인간 시료에 반응하며, 항원 친화 크로마토그래피로 정제됨. 액상 형태로 제공되며, 단기 4°C, 장기 -20°C 보관 권장.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:20–1:50
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human TMEM110. Recombinant protein control fragment (Product # RP-101617) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2648562 |
Product Specific Information
Immunogen sequence:
VDNFLMRKGK TKAKLEERGA NQDSRNGSKV RYRRAASHEE
Highest antigen sequence identity to the following orthologs:
- Mouse: 100%
- Rat: 100%
Target Information
Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites connecting the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER (PubMed:26322679, PubMed:26644574).
SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores (PubMed:26322679).
Acts by interacting with STIM1, promoting STIM1 conformational switch (PubMed:26322679).
Involved in STIM1 relocalization to ER-PM junctions (PubMed:26644574).
Contributes to the maintenance and reorganization of store-dependent ER-PM junctions (PubMed:26644574).
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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