Thermo Fisher Scientific RGS14 Polyclonal Antibody
RGS14 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF, ELISA 등 다양한 응용에 적합합니다. Human, Mouse, Rat 반응성이 있으며, 고순도 Protein A 정제 제품으로 안정적인 결과를 제공합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:400 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human RGS14, amino acids 151–250 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
RGS14 is a member of the regulator of G-protein signaling family, containing one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. It attenuates G-protein signaling by interacting with activated GTP-bound G alpha subunits and acts as a GTPase activating protein (GAP), promoting hydrolysis of GTP to GDP. This process allows formation of inactive G-protein heterotrimers, terminating the signal.
RGS14 also functions as a positive modulator of microtubule polymerization and spindle organization via a G(i)-alpha-dependent mechanism, playing roles in cell division, NGF-mediated neurite outgrowth, stress resistance, and hippocampal-based learning and memory.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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