Thermo Fisher Scientific IL21R Polyclonal Antibody
Human IL21R 단백질을 인식하는 Rabbit Polyclonal Antibody로 Western blot에 적합. Protein G로 정제된 액상 항체이며 PBS/gelatin buffer에 보관. IL21 신호전달 및 면역세포 활성 연구용.
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Applications
Western Blot (WB)
- Tested Dilution: 0.5–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptides (CSLHRSAHNATHATYT & CDFTSPGDEGPPRSYLR) corresponding to amino acids 65–80 and 505–521 of Human IL21R respectively |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 0.2% gelatin |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_1957524 |
Product Specific Information
PA1-29843 detects IL21-R from human samples.
Target Information
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and forms a heterodimeric receptor complex with the common gamma-chain, shared by receptors for IL2 and IL5.
This receptor mediates IL21-induced growth signals and is crucial for proliferation and differentiation of T cells, B cells, and NK cells.
Ligand binding activates downstream signaling molecules including JAK1, JAK3, STAT1, and STAT3.
Knockout studies in mice suggest a role in immunoglobulin regulation. Three alternatively spliced transcript variants encoding the same protein have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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