Thermo Fisher Scientific Human Superoxide Dismutase 4 Recombinant Protein

Applications

• Assay-dependent

Product Specifications

Product Specific Information

After reconstitution, store at -80°C and avoid freeze and thaw cycles.

Target Information

Superoxide dismutase (SOD) is an antioxidant enzyme involved in the defense system against reactive oxygen species (ROS).
SOD catalyzes the dismutation reaction of superoxide radical anion (O₂⁻) to hydrogen peroxide (H₂O₂), which is then converted to innocuous O₂ and H₂O by glutathione peroxidase and catalase.

Several classes of SOD have been identified:

• SOD1 (Cu,Zn-SOD): Intracellular, homodimeric 32 kDa enzyme containing one Cu and Zn ion per subunit, found in all eukaryotic species.
• SOD2 (Mn-SOD): Mitochondrial, 80 kDa tetrameric enzyme located in the mitochondrial matrix near the respiratory chain.
• SOD3 (EC-SOD): Extracellular, heparin-binding multimer of disulfide-linked dimers, mainly expressed in human lungs, vessel walls, and airways.
• SOD4 (CCS): Copper chaperone for superoxide dismutase, specifically delivers Cu to Cu/Zn-SOD and may activate it through direct insertion of the Cu cofactor.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.