Thermo Fisher Scientific BLVRA Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:5,000

Immunoprecipitation (IP)

• Tested Dilution: 2–10 µg/mg lysate

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt.

Target Information

Biliverdin reductase (BLVR) is a ubiquitously expressed, small cytoplasmic oxidoreductase that catalyzes the reduction of biliverdin to bilirubin. The first step of this process is catalyzed by heme oxygenase, which converts heme to iron, carbon monoxide, and biliverdin.
BLVR is unique among enzymes in being dual pH/dual cofactor-dependent, requiring NADH (pH 6.7) or NADPH (pH 8.7) as electron donors.
There are two isoforms:

• BLVRA (biliverdin-IX alpha-reductase): Major component in adult human liver
• BLVRB (biliverdin-IX beta-reductase): Found predominantly in fetal liver

Bilirubin, the product of BLVR activity, acts as an important biological antioxidant but can also be neurotoxic, contributing to conditions such as kernicterus. It also inhibits kinase activity and enzymes such as protein kinase C and NADPH oxidase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.