Thermo Fisher Scientific CBFB/PEBP2beta Monoclonal Antibody (PCRP-CBFB-1E6)

Applications and Tested Dilution

Product Specifications

Target Information

The CBFB gene encodes the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF family, which regulates genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2).
The beta subunit acts as a non-DNA-binding regulatory component, enhancing DNA binding by the alpha subunit as the complex interacts with various enhancer and promoter regions, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, and GM-CSF promoters.

Alternative splicing produces two mRNA variants encoding distinct C-terminal isoforms.
A pericentric inversion of chromosome 16 [inv(16)(p13q22)] can generate a chimeric transcript combining the N-terminus of core-binding factor beta with the C-terminal portion of smooth muscle myosin heavy chain 11, associated with acute myeloid leukemia (M4Eo subtype).

Two transcript variants encoding different isoforms have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.