Thermo Fisher Scientific CBFB/PEBP2beta Monoclonal Antibody (PCRP-CBFB-1E6)
CBFB/PEBP2beta 단백질을 인식하는 Thermo Fisher Scientific의 마우스 단일클론 항체입니다. Western blot, ICC/IF, Flow cytometry 등 다양한 응용에 사용 가능하며, 인간 시료에 반응합니다. 단백질 A/G로 정제된 액상 형태로 제공되며, 연구용으로만 사용됩니다.
- 카탈로그번호
- 865-MSM9-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CBFB/PEBP2beta Monoclonal Antibody (PCRP-CBFB-1E6)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10⁶ cells |
| ELISA | Assay-dependent |
| Immunoprecipitation (IP) | 1–2 µg/500 µg lysate |
| Peptide Array | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PCRP-CBFB-1E6 |
| Immunogen | Recombinant full-length human CBFB protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The CBFB gene encodes the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF family, which regulates genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2).
The beta subunit acts as a non-DNA-binding regulatory component, enhancing DNA binding by the alpha subunit as the complex interacts with various enhancer and promoter regions, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, and GM-CSF promoters.
Alternative splicing produces two mRNA variants encoding distinct C-terminal isoforms.
A pericentric inversion of chromosome 16 [inv(16)(p13q22)] can generate a chimeric transcript combining the N-terminus of core-binding factor beta with the C-terminal portion of smooth muscle myosin heavy chain 11, associated with acute myeloid leukemia (M4Eo subtype).
Two transcript variants encoding different isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.