Thermo Fisher Scientific Cell Surface Glycoprotein MUC18 Polyclonal Antibody, Biotin
Rat MUC18(Cell Surface Glycoprotein) 인식 Rabbit Polyclonal Antibody로, Biotin으로 결합된 제품입니다. Western blot, ELISA, Immunoprecipitation에 사용 가능하며, 고순도 Affinity chromatography로 정제되어 연구용으로 적합합니다.
- 카탈로그번호
- MUC18-BIOTIN
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Cell Surface Glycoprotein MUC18 Polyclonal Antibody, Biotin
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 330–353 on rat Cell Surface Glycoprotein MUC18 protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD146 (MCAM) is an integral membrane glycoprotein belonging to the immunoglobulin superfamily. It is expressed at cell–cell junctions in all endothelial cells and also observed in other normal and malignant cell types. CD146 functions as a calcium-independent cell adhesion molecule and as a signal transduction molecule recruiting Fyn kinase, leading to tyrosine phosphorylation of intracellular proteins involved in actin cytoskeleton assembly. It plays a role in endothelial cell adhesion and cohesion, melanoma cell interaction with vascular elements, and may be active in neural crest cells during embryonic development. CD146 also acts as a surface receptor triggering tyrosine phosphorylation of FYN and PTK2, and transiently increases intracellular calcium concentration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: MUC18-BIOTIN_CD146_Q9EPF2-1_Rabbit.svg)
(이미지: MUC18-BIOTIN_CD146_Q9EPF2-1_Rabbit_PDP.jpeg)
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