Thermo Fisher Scientific FOLR3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000–1:3,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total FOLR3.

Target Information

Folate is an essential vitamin obtained through intestinal absorption in mammals. Folate and reduced folic acid derivatives bind to the folate receptor (FR) family, mediating endocytosis of 5-methyltetrahydrofolate into the cell.
The folate receptor family consists of five members: alpha, beta, gamma, gamma' (produced by alternative splicing), and delta.

• β-FR: Attached to the membrane by a GPI anchor; expressed in malignant epithelial and nonepithelial tissues.
• γ-FR: Expressed in hematopoietic tissues such as spleen, thymus, and bone marrow.
• δ-FR: Expression pattern is highly restricted both spatially and temporally.
• α-FR: Used as a selective tumor marker and may be targeted for delivery of therapeutic compounds to tumor cells via folic acid derivatives.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.